APCgenebeta-catenin

由 J Yang 著作 · 2006 · 被引用 255 次 — Most colorectal cancers have mutations of the adenomatous polyposis coli (APC) gene or the β-catenin gene that stabilize β-catenin and activate β-catenin ...

由 TW Parker 著作 · 2020 · 被引用 81 次 — APC is an essential component of a cytoplasmic protein complex that targets β-catenin for destruction. Following Wnt ligand presentation, this ...

2013年3月1日 — One protein with which APC associates is beta-catenin. Beta-catenin helps control the activity (expression) of particular genes and promotes ...

由 Y Xiong 著作 · 2006 · 被引用 20 次 — The current model for the regulation of β-catenin by APC rests on the ability of APC to bind with β-catenin in the nucleus and export it out into the cytoplasm ...

The APC/β-catenin pathway is a signal transduction pathway important in development and tumorigenesis. Signaling by this pathway is defined as the stabilization ...

由 W Hankey 著作 · 2018 · 被引用 165 次 — APC interacts with both β-catenin and plakoglobin (γ-catenin) at cell-cell junctions [103], which function to connect adjacent epithelial cells, organize them ...

由 KE Spink 著作 · 2001 · 被引用 178 次 — APC binds to β-catenin through a series of homologous 15 and 20 amino acid repeats. We have determined the crystal structure of a 15 amino acid β-catenin ...

由 N Yedid 著作 · 2016 · 被引用 15 次 — A mutation in APC will result in a nonfunctional protein product that will lead to increased β-catenin levels. In search of the somatic ...